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ea0029p1136 | Neuroendocrinology | ICEECE2012

Leptin resistance and desensitization of hypophagia during prolonged inflammatory challenge are associated with high ptp1b expression in the hypothalamus

Borges B. , Rorato R. , Marangon P. , Uchoa E. , Antunes-Rodrigues J. , Elias L.

Repeated exposure to lipopolysaccharide (LPS) leads to endotoxin tolerance. Desensitization of hypophagia in response to repeated exposure to endotoxin is related to an inability of leptin to phosphorylate STAT-3 protein. Protein tyrosine phosphatase 1B (PTP1B) activity is known to contribute to leptin resistance by inhibiting leptin signaling. In this study, we induced endotoxin tolerance, injecting repeated LPS doses (6LPS) (100 μg/kg, i.p.) in comparison with single (1...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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